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Psilocybin-assisted psychotherapy for substance use disorders as a complex intervention: A systematic review of efficacy, mechanisms and psychotherapeutic frameworksJournal of Psychopharmacology · 2026-08-17Exploring the In Vitro Effect of Psilocybin on the Composition and Metabolic Activity of Gut Microbiota in Individuals with Severe AnxietyDrugs and Drug Candidates · 2026-08-12A Phase III, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With Treatment-resistant DepressionClinicalTrials.gov · 2026-08-10A Phase III, Multicentre, Randomised, Double-blind, Placebo-controlled Study to Investigate the Efficacy, Safety, and Tolerability of COMP360 in Participants With Treatment-resistant DepressionClinicalTrials.gov · 2026-08-10Impact of Psilocybin on Motor Function in Healthy Participants: A Phase 1, Randomised, Triple-Blind, Dose-Finding Study.CNS drugs · 2026-08-07Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial.Nature medicine · 2026-08-06Integration in classic psychedelic-assisted therapies for mental health conditions: A scoping reviewPsychedelics · 2026-07-26Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.Psychopharmacology · 2026-07-01An Open-Label Study of Single-Dose Psilocybin for Borderline Personality Disorder With Co-Occurring Major Depressive DisorderClinical Neuropharmacology · 2026-07-01Psilocybin restores behavior and 5-HT2A signaling while reducing microglial density after chronic traumatic brain injury in ratsCell Reports Medicine · 2026-07-01Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?British journal of pharmacology · 2026-07-01Psychedelics and autism spectrum disorder: Mechanistic insights, translational evidence and ethical challenges.Journal of psychiatric research · 2026-06-23Comparing Cannabis Use Motivations and Dependence Across Regular Cannabis Users Who Have or Have Not Recently Used Psilocybin.Cannabis and cannabinoid research · 2026-06-01Mapping cognitive-behavioral approach in psychedelic-assisted treatment: a systematic review across phases with classic and non-classic psychedelics.European archives of psychiatry and clinical neuroscience · 2026-06-01Therapeutic advances in fibromyalgia: one year in review 2026.Clinical and experimental rheumatology · 2026-06-01Psilocybin-assisted cognitive behavioral therapy for major depressive disorder: A pilot trialJournal of Affective Disorders · 2026-06-01Effects of psilocybin on sleep quality and brain microstructure in chronic cluster headacheJournal of Psychopharmacology · 2026-05-29Psilocybin-induced neurocardiogenic syncope: a case reportPsychopharmacology · 2026-05-28Sa1731 A PILOT STUDY OF OPEN-LABEL PSILOCYBIN-ASSISTED THERAPY IN TREATMENT-REFRACTORY IBSGastrointestinal Endoscopy · 2026-05-01Profiling the Cell-Type Specific Effects of Psilocybin in Medial Prefrontal CortexhBiological Psychiatry · 2026-05-01Pure psilocybin reduces reward-associated preference while mushroom extract shows transient exploratory effects in ratsRevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · 2026-05-01Preclinical evaluation of psilocybin and related compounds: Inhibition of cytochrome P450 isoformsRevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · 2026-05-01Cytochrome P450 Inhibition by Psilocybin and Psilocin: A Combined Molecular Dynamics and Enzymatic Screening StudyRevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · 2026-05-01Exploring Psilocybin-Assisted Schema Therapy: A Conceptual Framework for Potential Therapeutic Synergies in Personality Disorders.Trends in psychiatry and psychotherapy · 2026-04-25Sustained Effects of Low-to-Moderate Doses of Psilocybin on Brain ConnectivitymedRxiv · 2026-04-20Impact of psilocybin and Psilocybe cubensis extract on gut microbiota in Wistar Han ratsScience Letters · 2026-04-17Psilocybin and Psilocybe cubensis extract exhibit divergent behavioural and toxicological effects in ratsScience Letters · 2026-04-17An international mega-analysis of psychedelic drug effects on brain circuit function.Nature medicine · 2026-04-01Psychedelics in functional disorders: A scoping review.Progress in neuro-psychopharmacology & biological psychiatry · 2026-03-20Psilocin as a Broad Inhibitor of CYP450 Enzymes: Integrated In Vitro and In Silico EvidenceInstituto Politécnico do Porto · 2026-02-25Delayed psilocybin treatment after repeated mild traumatic brain injury recovers chronic behavioural deficits, reduces microglial density, and enhances hippocampal neurogenesis in ratsResearch Square · 2026-02-23Effects of Psilocybin and Select Pharmaceutical InteractionsMacEwan University Student eJournal · 2026-02-18Design, Synthesis, and Pharmacokinetic Profiling of Fluorinated Reversible N -Alkyl Carbamate Derivatives of Psilocin for Sub-Hallucinogenic Brain ExposureJournal of Medicinal Chemistry · 2026-02-12Low, non-psychedelic doses of psilocybin as a novel treatment for MASLD, obesity and type 2 diabetes via 5-HT2B receptor-dependent mechanismsRepository for Publications and Research Data (ETH Zurich) · 2026-01-20XÂY DỰNG PHƯƠNG PHÁP ĐỊNH LƯỢNG PSILOCIN VÀ PSILOCYBIN TRONG HUYẾT TƯƠNG NGƯỜI BẰNG LC-MS/MSTNU Journal of Science and Technology · 2026-01-13Associations of Couples' Psychedelic Use with Shared Reality and Relational Well-Being.Journal of psychoactive drugs · 2026-01-06Reported Safety Practices of Publicly Advertised Psychedelic Retreats.JAMA network open · 2026-01-02Additional file 1 of An open-label pilot study of psilocybin-assisted therapy for binge eating disorderFigshare · 2026-01-01Additional file 2 of An open-label pilot study of psilocybin-assisted therapy for binge eating disorderFigshare · 2026-01-01Electrical brain changes following psilocybin administration in sprague-dawley ratsNeuroscience Applied · 2026-01-01An exploration of the relationships between the effects of psilocybin on behavior, 5-HT receptor occupancy, and neuroplastic effects in mice.Journal of psychopharmacology (Oxford, England) · 2026-01-01Indigenous Knowledge Systems & Psychedelic Science: Towards Ethical and Reciprocal Collaboration.Journal of psychopharmacology (Oxford, England) · 2026-01-01Systematic study of (, ) sensu lato and psilocybin-producing traits of species from China.IMA fungus · 2026-01-01The Effect of on Spatial Memory and BDNF Expression in Male Rats Exposed to Chronic Unpredictable Mild Stress.Journal of psychoactive drugs · 2026-01-01Thirty Years of Ibogaine Research: A Literature Review on Clinical Perspectives.Journal of clinical psychopharmacology · 2026-01-01A Randomised, Triple-Blind, Dose-Finding Study of the Impact of Psilocybin on Motor Function in Healthy ParticipantsmedRxiv · 2025-12-23Cognitive outcomes following psilocybin-assisted therapy in treatment-resistant depression: A post-hoc analysis of a randomized, waitlist-controlled trial.Progress in neuro-psychopharmacology & biological psychiatry · 2025-12-20Psilocybin as a fast-acting and long-lasting antidepressant for adolescence: Proposing NeuroD1 as a biomarker of its long-term plasticity.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025-12-01Psilocybin and Chronic Pain: A New Perspective for Future Pain Therapists?Medical sciences (Basel, Switzerland) · 2025-11-20Psilocybin's effects on obsessive-compulsive behaviors: A systematic review of preclinical and clinical evidencePsychedelics. · 2025-10-27Multianalytical Investigation of Psilocybe cubensis Mushrooms: Physicochemical Characterization and Biological Evaluation of Psilocybin and Psilocin CompoundsACS Omega · 2025-09-30317. PSILOCYBIN DOES NOT INDUCE CONDITIONED PLACE PREFERENCE, BUT MODIFIES BEHAVIORAL PATTERNS IN SPRAGUE-DAWLEY RATSThe international journal of neuropsychopharmacology · 2025-08-01476. ACUTE AND CHRONIC PSILOCYBIN IN MOUSE MODELS OF PSYCHIATRIC DISORDERSThe international journal of neuropsychopharmacology · 2025-08-01Chemical Composition and Biological Activities of Mushrooms: Gaps and Perspectives.Pharmaceuticals (Basel, Switzerland) · 2025-07-01The intensity of the psychedelic experience is reliably associated with clinical improvements: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2025-05-01Exploring Factors Affecting Psychological Flexibility After Psychedelic Experiences.Journal of psychoactive drugs · 2025-04-25187. Changes in Symptoms of Anhedonia With Psilocybin-Assisted Psychotherapy: A Secondary Analysis of a Randomized Clinical Trial for Treatment-Resistant DepressionBiological Psychiatry · 2025-04-09186. Assessing Cognitive Outcomes in Treatment-Resistant Depression Following Psilocybin-Assisted PsychotherapyBiological Psychiatry · 2025-04-09323. Comparing Antidepressant Effects of Psilocybin-Assisted Psychotherapy in Individuals That Were Unmedicated at Initial Screening Versus Individuals Discontinuing Medications for Study ParticipationBiological Psychiatry · 2025-04-09Exploring factors associated with the intensity of a mystical experience following naturalistic psychedelic use: A retrospective survey.Progress in neuro-psychopharmacology & biological psychiatry · 2025-03-20Exploring Public Sentiments of Psychedelics Versus Other Substances: A Reddit-Based Natural Language Processing StudyPsyArXiv · 2025-03-07Exploring Public Sentiments of Psychedelics Versus Other Substances: A Reddit-Based Natural Language Processing StudyPsyArXiv · 2025-03-07Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression in Bipolar II Disorder.Psychedelic medicine (New Rochelle, N.Y.) · 2025-03-01ANXIOLYTIC- AND PROCOGNITIVE-LIKE EFFECTS OF A30-DAY CHRONIC TREATMENT WITH A LOW NON-PSYCHEDELIC DOSE OF PSILOCYBIN IN C57BL/6J MICEThe international journal of neuropsychopharmacology · 2025-02-01Uncovering Psychedelics: From Neural Circuits to Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2025-01-19Molecular Phylogeny and Morphology Reveal Four New Species of (Bolbitiaceae, Agaricales) from the Qinghai-Xizang Plateau, China.Journal of fungi (Basel, Switzerland) · 2025-01-07Neurotoxic and Neuroprotective Effects of Psychedelics in a Human Neuroblastoma Cell ModelRevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · 2025-01-01The phenomenology of psilocybin: transformative insights for research and clinical practice.Frontiers in psychology · 2025-01-01Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel Syndrome.Journal of clinical gastroenterology · 2025-01-01Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis.Frontiers in psychiatry · 2025-01-01Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial.EClinicalMedicine · 2024-10-01[Psychedelic and dissociative agents in psychiatry: challenges in the treatment].Der Nervenarzt · 2024-09-01Effect of chemically synthesized psilocybin and psychedelic mushroom extract on molecular and metabolic profiles in mouse brain.Molecular psychiatry · 2024-07-01Ketamine-Induced Unresponsiveness Shows a Harmonic Shift from Global to Localised Functional OrganisationbioRxiv · 2024-06-25THU-285 Lownonpsychedelic dosed of psilocybin for the therapy of MASLDJournal of Hepatology · 2024-05-31The Classical Psychedelic Psilocybin Mitigates Oxycodone WithdrawalJournal of Pharmacology and Experimental Therapeutics · 2024-05-13Effects of discontinuation of serotonergic antidepressants prior to psilocybin therapy versus escitalopram for major depression.Journal of psychopharmacology (Oxford, England) · 2024-05-01Safety and risk assessment of psychedelic psychotherapy: A meta-analysis and systematic review.Psychiatry research · 2024-05-01Psychedelics and the 'inner healer': Myth or mechanism?Journal of psychopharmacology (Oxford, England) · 2024-05-01A comparison between psilocybin and esketamine in treatment-resistant depression using number needed to treat (NNT): A systematic review.Journal of affective disorders · 2024-04-01Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin.Med (New York, N.Y.) · 2024-03-08Antidepressant- and anxiolytic-like activities and acute toxicity evaluation of the Psilocybe cubensis mushroom in experimental models in mice.Journal of ethnopharmacology · 2024-02-10Psychedelics and sexual functioning: a mixed-methods study.Scientific reports · 2024-02-07Non-psychedelic doses of psilocybin as a novel therapeutic approach for MASLDDigestive and Liver Disease · 2024-02-01Brazilian Psychedelic Science and the Frontiers of PsychiatryJornal Brasileiro de Psiquiatria · 2024-01-01CCH attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity.Headache · 2024-01-01Alterations in brain network connectivity and subjective experience induced by psychedelics: a scoping review.Frontiers in psychiatry · 2024-01-01Study protocol for "Psilocybin in patients with fibromyalgia: brain biomarkers of action".Frontiers in psychiatry · 2024-01-01Distinctive Molecular and Metabolic Profiles of Chemically Synthesized Psilocybin and Psychedelic Mushroom ExtractResearch Square · 2023-07-20In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape.Science advances · 2023-06-16Psychedelics reopen the social reward learning critical periodNature · 2023-06-13Therapeutic role of psilocybin and 3,4-methylenedioxymethamphetamine in trauma: A literature review.World journal of psychiatry · 2023-05-19Cardiac Arrest Associated With Psilocybin Use and Hereditary Hemochromatosis.Cureus · 2023-05-01Behavioral effects of a 14-day repeated treatment with psilocybin at a low non-psychedelic dose: a preliminary study in C57BL/6J miceNeuroscience Applied · 2023-01-01The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: Serotonergic Psychedelic Treatments for Major Depressive Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023-01-01Validation of a French Version of the Mystical Experience Questionnaire with Retrospective Reports of the Most Significant Psychedelic Experience among French Users.Journal of psychoactive drugs · 2023-01-01Bedside to bench: the outlook for psychedelic research.Frontiers in pharmacology · 2023-01-01Group psychedelic therapy: empirical estimates of cost-savings and improved access.Frontiers in psychiatry · 2023-01-01Psilocybin for Depression: From Credibility to Feasibility, What's Missing?Pharmaceuticals (Basel, Switzerland) · 2022-12-31Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and Psilocybin: Translational Implications.International journal of molecular sciences · 2022-11-16A Research Domain Criteria (RDoC)-Guided Dashboard to Review Psilocybin Target Domains: A Systematic Review.CNS drugs · 2022-10-01Effects of psilocybin versus escitalopram on rumination and thought suppression in depression.BJPsych open · 2022-09-06P03-21 Magic mushrooms and psilocybin: pharmacokinetics, pharmacodynamics, and clinical applicationsToxicology Letters · 2022-09-01P03-18 Simultaneous detection and quantification of psilocybin and psilocin by gas chromatography coupled to mass spectrometry (GC-MS)Toxicology Letters · 2022-09-01Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 receptors in the head twitch response induced by 5-hydroxytryptophan and psilocybin: Translational implicationsbioRxiv · 2022-07-23Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter LandscapebioRxiv · 2022-07-13Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivitymedRxiv · 2022-07-10The Effects of Psilocybin in Adults with Major Depressive Disorder and the General Population: Findings from Neuroimaging Studies.Psychiatry research · 2022-07-01The Therapeutic Potential of Psychedelic-assisted Therapies for Symptom Control in Patients Diagnosed With Serious Illness: A Systematic Review.Journal of pain and symptom management · 2022-06-01Production and extraction of psilocybin and psilocin from Psilocybe spp. mushroomsRevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · 2022-04-06Evaluation of a quantitative analytical method for psilocin and psilocybin using HPLC-DADRevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · 2022-04-06Psylocybin and Psilocin as new tools to fight depression: an overview of the Pharmacodynamic and pharmacokinetic mechanismsRevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · 2022-04-06Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective?Journal of xenobiotics · 2022-02-07Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression.CNS drugs · 2022-01-01Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta-Serine/Threonine Kinase-Mammalian Target of Rapamycin Complex 1 Pathway.Frontiers in veterinary science · 2022-01-01Music programming for psilocybin-assisted therapy: Guided Imagery and Music-informed perspectives.Frontiers in psychology · 2022-01-01Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism.Science advances · 2021-11-19Magic mushroom: all is not as it seems.Acta chirurgica Belgica · 2021-09-30Use of alternative therapy with Psilocybin in oncologic patients with depression and/or anxiety disorders - integrative reviewResearch Society and Development · 2021-08-19[Efficacy of psychedelics in psychiatry, a systematic review of the literature].L'Encephale · 2021-08-01Clinical and biological predictors of psychedelic response in the treatment of psychiatric and addictive disorders: A systematic review.Journal of psychiatric research · 2021-05-01[Ketamine, psilocybin, and rapid acting antidepressant: new promise for psychiatry?].L'Encephale · 2021-04-01Low Doses of Psilocybin and Ketamine Enhance Motivation and Attention in Poor Performing Rats: Evidence for an Antidepressant Property.Frontiers in pharmacology · 2021-01-01The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies.Frontiers in pharmacology · 2021-01-01The emerging role of psilocybin and MDMA in the treatment of mental illness.Expert review of neurotherapeutics · 2020-12-01Efficacy of psychedelic treatments on depressive symptoms: A meta-analysis.Journal of psychopharmacology (Oxford, England) · 2020-10-01The Psilocin (4-hydroxy-N,N-dimethyltryptamine) and Bufotenine (5-hydroxy-N,N-dimethyltryptamine) Case: Ensuring the Correct Isomer has Been IdentifiedJournal of Forensic Sciences · 2020-09-01[Addictions].Revue medicale suisse · 2020-01-15Psychedelic-assisted therapies: The past, and the need to move forward responsibly.The International journal on drug policy · 2019-08-01Pharmacological interventions targeting anhedonia in patients with major depressive disorder: A systematic review.Progress in neuro-psychopharmacology & biological psychiatry · 2019-06-08The psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network.PloS one · 2015-01-01Spatiotemporal brain dynamics of emotional face processing modulations induced by the serotonin 1A/2A receptor agonist psilocybin.Cerebral cortex (New York, N.Y.: 1991) · 2014-12-01Acute toxicity of Psilocybe cubensis (Ear.) Sing., Strophariaceae, aqueous extract in miceRevista Brasileira de Farmacognosia · 2010-07-01Psilocybin: reaction with a fraction of rat brain.Science (New York, N.Y.) · 1967-01-13Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and PsilocybinThe Journal of Psychology · 1960-01-01