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1,711 matching records. Adjust the search and filters above.

Therapeutic Divergence in 5-HTA Agonism: Psilocybin and Phenalkylamines for Demoralization Syndrome.

ACS medicinal chemistry letters 2025-09-11 Kargbo RB DOI 10.1021/acsmedchemlett.5c00475

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Depression Receptor Pharmacology Safety Other All topics and provenance

Correction: Therapeutic and legal aspects of psilocybin in cancer-related depression.

Frontiers in psychiatry 2025-01-01 Wierzbicka M, Kopczyk R, Gerlach A, Rymaszewska J DOI 10.3389/fpsyt.2025.1698185

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Depression Cancer Patients Other All topics and provenance

Preliminary validation and refinement of the psychedelic aesthetic experience questionnaire.

Frontiers in psychology 2025-01-01 Hooper JF, Ellingson JM, Hutchison KE DOI 10.3389/fpsyg.2025.1648968

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Depression Anxiety Addiction Observational Study All topics and provenance

Reappraisal of the hype and hope offered by psilocybin treatment of depression.

The New Zealand medical journal 2025-09-19 Beaglehole B, Manuel J DOI 10.26635/6965.7138

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Depression Review Article Treatment-Resistant Depression Review Article All topics and provenance

Psilocybin-assisted group psychotherapy and mindfulness-based stress reduction for frontline healthcare provider COVID-19-related depression and burnout: A randomized controlled trial.

PLoS medicine 2025-09-01 Lewis BR, Hendrick J, Byrne K, Odette M, Wu C, Garland EL DOI 10.1371/journal.pmed.1004519

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Depression Randomized Controlled Trial Observational Study Randomized Controlled Trial All topics and provenance

Psilocybin-assisted psychotherapy for methamphetamine use disorder: A pilot open-label safety and feasibility study.

Addiction (Abingdon, England) 2025-09-20 Knock E, Siefried KJ, Bedi G, Albert S, Day RO, Ezard N DOI 10.1111/add.70187

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Depression Anxiety Headache / Migraine Randomized Controlled Trial All topics and provenance

Comparing Antidepressant Effects of Psilocybin-Assisted Psychotherapy in Individuals That Were Unmedicated at Initial Screening Versus Individuals Discontinuing Medications for Study Participation: Comparaison des effets antidépresseurs de la psychothérapie assistée par la psilocybine (PAP) chez les personnes non médicamentées à la sélection initiale et les personnes ayant arrêté les médicaments pour participer à l'étude.

Canadian journal of psychiatry. Revue canadienne de psychiatrie 2025-10-01 Chisamore N, Kaczmarek ES, Doyle Z, Johnson DE, Weiglein G, Meshkat S DOI 10.1177/07067437251328316

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Depression Anxiety Mystical Experience Clinical Trial All topics and provenance

Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs.

Psychopharmacology 2025-10-01 Borgogna NC, Owen T, Petrovitch D, Vaughn J, Johnson DAL, Pagano LA DOI 10.1007/s00213-025-06788-w

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Depression Mechanism of Action Randomized Controlled Trial Randomized Controlled Trial All topics and provenance

Correction to: Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs.

Psychopharmacology 2025-10-01 Borgogna NC, Owen T, Petrovitch D, Vaughn J, Johnson DAL, Pagano LA DOI 10.1007/s00213-025-06818-7

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Depression Randomized Controlled Trial Meta-Analysis Randomized Controlled Trial All topics and provenance

Single-dose (10 mg) psilocybin reduces symptoms in adults with obsessive-compulsive disorder: A pharmacological challenge study.

Comprehensive psychiatry 2025-10-01 Pellegrini L, Fineberg NA, O'Connor S, De Souza AMFLP, Godfrey K, Reed S DOI 10.1016/j.comppsych.2025.152619

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Depression OCD Mechanism of Action Clinical Trial All topics and provenance

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.

Neuron 2025-10-01 Jain MK, Gumpper RH, Slocum ST, Schmitz GP, Madsen JS, Tummino TA DOI 10.1016/j.neuron.2025.06.012

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Depression Anxiety PTSD Other All topics and provenance

Endocannabinoids, depression, and treatment resistance: Perspectives on effective therapeutic interventions.

Psychiatry research 2025-10-01 Rosa I, Padula LP, Semeraro F, Marrangone C, Inserra A, De Risio L DOI 10.1016/j.psychres.2025.116697

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Depression Mechanism of Action Receptor Pharmacology Review Article All topics and provenance

Concomitant use of antidepressants and classic psychedelics: A scoping review.

Journal of psychopharmacology (Oxford, England) 2025-10-01 Tap SC, Thomas K, Páleníček T, Stenbæk DS, Oliveira-Maia AJ, van Dalfsen JH DOI 10.1177/02698811251368360

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Depression Receptor Pharmacology Review Article Clinical Trial All topics and provenance

Serotonin 5-HT Receptor Signaling Analysis Reveals Psychedelic Biased Agonism.

ACS chemical neuroscience 2025-10-01 Bonniwell EM, Alabdali R, Hennessey JJ, McKee JL, Cavalco NG, Lammers JC DOI 10.1021/acschemneuro.5c00647

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Depression Mechanism of Action Receptor Pharmacology Other All topics and provenance

[Role of psychedelics in psychiatry: a true therapeutic revolution or a trend?].

La Revue du praticien 2025-10-01 Sabé M, Seragnoli F, Penzenstadler L, Thorens G

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Depression Anxiety PTSD Clinical Trial All topics and provenance

Psilocybin-assisted psychotherapy in adults with depression - A literature review.

Progress in neuro-psychopharmacology & biological psychiatry 2025-10-02 Dorczok MC, Mittmann G, Ettl T, Steiner-Hofbauer V DOI 10.1016/j.pnpbp.2025.111508

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Depression Mechanism of Action Review Article Review Article All topics and provenance

Psilocybin with psychotherapeutic support for treatment-resistant depression: a pilot clinical trial.

Therapeutic advances in psychopharmacology 2025-01-01 Meikle S, Carter O, Liknaitzky P, Johansen L, Iyer R, Strauss N DOI 10.1177/20451253251377187

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Depression Spirituality Clinical Trial Clinical Trial All topics and provenance

Psilocybin Enhances Cued Fear Extinction and Extinction Recall in Stress-Naïve, Acutely Stressed, and Chronically Stressed Mice.

ACS pharmacology & translational science 2025-10-10 Razidlo J, Cataldo N, Wenthur CJ DOI 10.1021/acsptsci.5c00462

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Depression Anxiety PTSD Clinical Trial All topics and provenance

Biological markers of treatment response to serotonergic psychedelic therapies: a systematic review.

Therapeutic advances in psychopharmacology 2025-01-01 Wong S, Jones BDM, Thiyagarajah MT, Sabbah SG, Thompson C, Solmi M DOI 10.1177/20451253251384513

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Depression Brain Imaging Mechanism of Action Systematic Review All topics and provenance

Structure-Guided Design of Novel 5-HT Partial Agonists as Psychedelic Analogues with Antidepressant Effects.

Journal of medicinal chemistry 2025-10-23 Li R, Yan H, Chen Y, Liu Y, Tang L, Yu J DOI 10.1021/acs.jmedchem.5c02045

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Depression Receptor Pharmacology Animal Study Animal Study All topics and provenance

Research guides and tools

Database details

4,925 Psilocybin records 696 Psilocin records 1,491 Journal labels 66 Research topics

Published 4,372 Published / formal records Preprints 462 Marked as not peer reviewed Clinical trial registrations 310 ClinicalTrials.gov records Protocols 3 Study protocol records

Substance categories overlap; their counts must not be summed. Journal labels exclude preprint and trial-registry venues and may include name variants. Research topics are derived screening categories. Publication status does not independently verify peer review.

Publication timeline

4,045 records since 2020

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Top journals 1,491 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	154
Journal of psychoactive drugs	100
Frontiers in psychiatry	93
Psychopharmacology	91
Neuroscience Applied	57
Journal of Psychedelic Studies	49
Psychedelic medicine (New Rochelle, N.Y.)	40
Scientific reports	37
Journal of affective disorders	34
Psychiatric News	33

Research topics 66 topic filters

Depression 1,816 Receptor Pharmacology 1,315 Safety 1,268 Review Article 1,123 Mechanism of Action 1,122 Clinical Trial 1,030 Anxiety 925 Addiction 849 Pharmacology 776 Animal Study 552 General 548 Observational Study 543 Aging 539 Brain Imaging 494 Treatment-Resistant Depression 441 Emotional Processing 427 Neuroplasticity 422 PTSD 413

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,590	50.3%	Active
OpenAlex	1,190	23.1%	Active
Crossref	429	8.3%	Active
ClinicalTrials.gov	310	6%	Active
Europe PMC	264	5.1%	Active
PsyArXiv	188	3.7%	Active
bioRxiv	131	2.5%	Active

Psilocybin research database

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